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Solubility of SB-PT004 in various excipients

Journal: Tuberculosis (Edinburgh, Scotland)

Article Title: Formulation Studies of InhA inhibitors and Combination therapy to improve efficacy against Mycobacterium tuberculosis

doi: 10.1016/j.tube.2016.07.016

Figure Lengend Snippet: Solubility of SB-PT004 in various excipients

Article Snippet: The supernatant was collected and diluted as necessary with methanol for analysis with LC/MS/MS. table ft1 table-wrap mode="anchored" t5 caption a7 Vehicle Percent Solution, Solubility mg/ml HLB Co-solvents Ethanol (EtOH, Aaper) 20% 0.0034 ± 0.00033 Propylene Gycol (PG, Sigma Aldrich) 40% 0.0268 ± 0.0073 Polyethylene Glycol 400 (PEG-400, Sigma Aldrich) 40% 0.125 ± 0.0248 Surfactants Tween 20 10% 21.5 ± 0.1 16.7 Tween 80 10% 16.4 ± 0.6 15 Solutol HS15(BASF) 10% 19 ± 1.8 16.3 Cremohor EL (BASF) 10% 19 ± 2.3 13 Lipids Captex 200 P (Abitec Corp) 496.5 ± 47.4 3.8 Captex 300 (Abitec Corp) 216 ± 13.5 Capmul MCM NF (Abitec Corp) N/A 5-6 Open in a separate window Solubility of SB-PT004 in various excipients 2.2.

Techniques: Solubility